Dynamics of stomach bacteria revealed for the first time as stomach cancer progresses in Chile
핵심 요약
- Researchers in Chile characterized changes in the stomach microbiome during the course of stomach cancer for the first time.
- In advanced stages of the disease, Helicobacter pylori was replaced by Lactobacillus and Limosilactobacillus species.
- Bacterial changes could be used as new biomarkers for early diagnosis in the future.
- The study was conducted through the analysis of 162 tissue samples from 83 patients in Magallanes and Santiago.
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Researchers at the UMAG Faculty of Medicine in Chile have presented a study to the scientific world that reveals for the first time how stomach bacteria change during the progression of stomach cancer. Published in the journal Frontiers in Microbiology, the research examined the process ranging from benign lesions such as gastritis to advanced-stage stomach cancer. This doctoral study, conducted by Daniela Zapata, was recorded as a significant scientific milestone in understanding microbiotal dynamics specific to the Chilean population.
The study determined that in the advanced stages of the disease, the *Helicobacter pylori* bacterium was replaced by species such as *Lactobacillus* and *Limosilactobacillus*. Researchers anticipate that these bacterial changes could be used as new biomarkers to determine patients' risk levels in the future. The study, which utilized a long-read sequencing technology called Nanopore, serves a complementary nature to existing traditional diagnostic methods.
The research is based on data from the MAGIC Cohort and the University of Chile Biobank (BTUCH), which have been active since 2018. In the project, where 162 tissue samples from 83 patients in the Magallanes and Santiago regions were analyzed, the differences in bacterial composition according to disease stages and regions were detailed. Scientists emphasize the importance of strengthening biological data collections to develop personalized cancer prevention strategies.
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- What innovation does the mentioned research offer in the diagnosis of stomach cancer?
- The research revealed the changes in stomach bacteria parallel to the progression of the disease. It anticipates that these bacterial structures could be used as biomarkers determining patients' risk levels in the future.
- What bacterial changes were observed in the advanced stages of stomach cancer in the study?
- It was determined that the Helicobacter pylori bacterium, which is common in early lesions, decreased in advanced cancer stages; conversely, Lactobacillus and Limosilactobacillus species increased.
- On what data was the research conducted?
- It was conducted through the analysis of 162 tissue samples belonging to 83 patients collected from the MAGIC Cohort in the Magallanes region and the biobank (BTUCH) in Santiago.